产品详情
简单介绍:
Mouse Basigin/CD147 protein (Recombinant) (C-His&Avi) (STJP001460)
详情介绍:
Host: | HEK293 cells |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Recombinant-Mouse Basigin/CD147-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications. |
Formulation: | Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
Gene Symbol: | Bsg |
Gene ID: | 12215 |
Uniprot ID: | BASI_MOUSE |
Immunogen: | Recombinant Mouse Basigin/CD147 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala22-Ala211) of mouse CD147/EMMPRIN/Basigin (Accession #NP_033898.1) fused with a 6×His, Avi tag at the C-terminus. |
Post Translational Modifications | Isoform 1: N-glycosylated. Isoform 2: N-glycosylated. During spermatogenesis, probably deglycosylated during epididymal transit. |
Function | Isoform 1: Essential for normal retinal maturation and development. Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors. In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors. Isoform 2: Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells. Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling. Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells. Plays an important role in spermatogenesis.mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids. |
Protein Name | Basigin Basic Immunoglobulin Superfamily Ht7 Antigen Membrane Glycoprotein Gp42 Cd Antigen Cd147 |
Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Photoreceptor Inner Segment Cell Projection Cilium Photoreceptor Outer Segment Isoform 2: Cell Membrane Endoplasmic Reticulum Membrane Basolateral Cell Membrane |
Alternative Protein Names | Basigin protein Basic Immunoglobulin Superfamily protein Ht7 Antigen protein Membrane Glycoprotein Gp42 protein Cd Antigen Cd147 protein Bsg protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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