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  • 产品名称：Mouse c-Kit/CD117 protein (Recombinant) (C-His) (STJP001497)

  • 产品型号：STJP001497
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse c-Kit/CD117 protein (Recombinant) (C-His) (STJP001497)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse c-Kit/CD117-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: Kit
Gene ID: 16590
Uniprot ID: KIT_MOUSE
Immunogen: Recombinant Mouse c-Kit/CD117 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser25-Pro527) of mouse KIT/c-KIT/CD117 (Accession #NP_001116205.1) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation. Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation of isoform 1 and isoform 2. Isoform 1 shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF, while isoform 2 requires stimulation by KITLG/SCF for phosphorylation (in vitro). Phosphorylation of Tyr-573 is required for interaction with PTPN6/SHP-1. Phosphorylation of Tyr-571 is required for interaction with PTPN11/SHP-2. Phosphorylated tyrosine residues are important for interaction with specific binding partners.
Function Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
Protein Name Mast/Stem Cell Growth Factor Receptor Kit
Scfr
Proto-Oncogene C-Kit
Tyrosine-Protein Kinase Kit
Cd Antigen Cd117
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-1433557
Reactome: -MMU-1433559
Reactome: -MMU-5673001
Reactome: -MMU-6811558
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Isoform 3: Cytoplasm
Detected In The Cytoplasm Of Spermatozoa
Especially In The Equatorial And Subacrosomal Region Of The Sperm Head
Alternative Protein Names Mast/Stem Cell Growth Factor Receptor Kit protein
Scfr protein
Proto-Oncogene C-Kit protein
Tyrosine-Protein Kinase Kit protein
Cd Antigen Cd117 protein
Kit protein
Sl protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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