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  • 产品名称：Anti-Alfy/WDFY3 antibody (Internal) (STJ73103)

  • 产品型号：STJ73103-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Alfy/WDFY3 antibody (Internal) (STJ73103)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Alfy/WDFY3 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: WDFY3
Gene ID: 23001
Uniprot ID: WDFY3_HUMAN
Immunogen Region: Internal
Accession Number: NP_055806.2
Immunogen Sequence: SPERSTRTQQKEFQT
Function Required for selective macroautophagy (aggrephagy). Acts as an adapter protein by linking specific proteins destined for degradation to the core autophagic machinery members, such as the ATG5-ATG12-ATG16L E3-like ligase, SQSTM1 and LC3. Along with p62/SQSTM1, involved in the formation and autophagic degradation of cytoplasmic ubiquitin-containing inclusions (p62 bodies, ALIS/aggresome-like induced structures). Along with SQSTM1, required to recruit ubiquitinated proteins to PML bodies in the nucleus. Important for normal brain development. Essential for the formation of axonal tracts throughout the brain and spinal cord, including the formation of the major forebrain commissures. Involved in the ability of neural cells to respond to guidance cues. Required for cortical neurons to respond to the trophic effects of netrin-1/NTN1. Regulates Wnt signaling through the removal of DVL3 aggregates, likely in an autophagy-dependent manner. This process may be important for the determination of brain size during embryonic development. May regulate osteoclastogenesis by acting on the TNFSF11/RANKL - TRAF6 pathway. After cytokinetic abscission, involved in midbody remnant degradation. In vitro strongly binds to phosphatidylinositol 3-phosphate (PtdIns3P).
Protein Name Wd Repeat And Fyve Domain-Containing Protein 3
Autophagy-Linked Fyve Protein
Alfy
Cellular Localisation Nucleus Membrane
Cytoplasm
Cytosol
Nucleus
Pml Body
Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Perikaryon
Cell Projection
Axon
Relocalization From The Nucleus To The Cytosol Is Stimulated By Cellular Stress
Such As Starvation Or Proteasomal Inhibition
In The Cytosol Of Starved Cells
Colocalizes With Autophagic Structures
This Redistribution Is Dependent On P62/Sqstm1
When Nuclear Export Is Blocked By Treatment With Leptomycin B
Accumulates In Nuclear Bodies
That Completely Or Partially Colocalize With Promyelocytic Leukemia (Pml) Bodies
Localizes Throughout Neurons
Including Within Axons
In Neurons
Enriched In The Light Membrane Fraction Along With The Synaptosomal Membrane Protein Synaptophysin And The Membrane-Bound Form Of Lc3/Map1lc3a/Map1lc3b
Called Lc3-Ii
A Classic Marker For Autophagic Vesicles
Alternative Antibody Names Anti-Wd Repeat And Fyve Domain-Containing Protein 3 antibody
Anti-Autophagy-Linked Fyve Protein antibody
Anti-Alfy antibody
Anti-WDFY3 antibody
Anti-KIAA0993 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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