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  • 产品名称：RASGRF2 Positive Control for STJ502753 peptide (STJ505087)

  • 产品型号：STJ505087-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
RASGRF2 Positive Control for STJ502753 peptide (STJ505087)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: RASGRF2 Positive Control for STJ502753 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RASGRF2
Gene ID: 5924
Uniprot ID: RGRF2_HUMAN
Specificity: This is positive control is recommended for use in combination with RASGRF2 antibody STJ502753.
Tissue Specificity Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level).
Post Translational Modifications Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome.
Function Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation.
Peptide Name Ras-Specific Guanine Nucleotide-Releasing Factor 2
Ras-Grf2
Ras Guanine Nucleotide Exchange Factor 2
Database Links Reactome: R-HSA-193648
Reactome: R-HSA-416482
Reactome: R-HSA-442982
Reactome: R-HSA-5673001
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Translocates To Membranes When Activated
Found Both At Cell Periphery And Along The Axon Of Neurons
Alternative Peptide Names Ras-Specific Guanine Nucleotide-Releasing Factor 2 protein
Ras-Grf2 protein
Ras Guanine Nucleotide Exchange Factor 2 protein
RASGRF2 protein
GRF2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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