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  • 产品名称：Anti-ARG1 antibody (200-322 aa) [ABT-Arg1] (STJ197017)

  • 产品型号：STJ197017
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARG1 antibody (200-322 aa) [ABT-Arg1] (STJ197017)
详情介绍：
Host: Mouse
Applications: IHC/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Arginase-1 (200-322 aa) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Monoclonal
Clone ID: ABT-Arg1
Conjugation: Unconjugated
Isotype: IgG2bk
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Dilution Range: IHC-P 1:100-500
WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARG1
Gene ID: 383
Uniprot ID: ARGI1_HUMAN
Immunogen Region: 200-322 aa
Specificity: This antibody detects endogenous levels of human Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase). Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as ant
Immunogen: Synthesized peptide derived from the human Arginase-1 at the amino acid range 200-322
Function Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively.the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion. In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure.
Protein Name Arginase-1
Liver-Type Arginase
Type I Arginase
Database Links Reactome: R-HSA-6798695
Reactome: R-HSA-70635
Cellular Localisation Cytoplasm
Cytoplasmic Granule
Localized In Azurophil Granules Of Neutrophils
Alternative Antibody Names Anti-Arginase-1 antibody
Anti-Liver-Type Arginase antibody
Anti-Type I Arginase antibody
Anti-ARG1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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