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  • 产品名称：Mouse CD8a protein (Recombinant) (C-hFc) (STJP001508)

  • 产品型号：STJP001508
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CD8a protein (Recombinant) (C-hFc) (STJP001508)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CD8a-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: Cd8a
Gene ID: 12525
Uniprot ID: CD8A_MOUSE
Immunogen: Recombinant Mouse CD8a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys28-Tyr196) of mouse CD8 alpha (Accession #NP_001074579.1) fused with a hFc tag at the C-terminus.
Function Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
Protein Name T-Cell Surface Glycoprotein Cd8 Alpha Chain
T-Cell Surface Glycoprotein Lyt-2
Cd Antigen Cd8a
Database Links Reactome: R-MMU-198933
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cd8a Localizes To Lipid Rafts Only When Associated With Its Partner Cd8b
Alternative Protein Names T-Cell Surface Glycoprotein Cd8 Alpha Chain protein
T-Cell Surface Glycoprotein Lyt-2 protein
Cd Antigen Cd8a protein
Cd8a protein
Lyt-2 protein
Lyt2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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