产品详情
查看大图

  • 产品名称：Mouse ENPP-2/Autotaxin protein (Recombinant) (C-His) (STJP002335)

  • 产品型号：STJP002335-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Mouse ENPP-2/Autotaxin protein (Recombinant) (C-His) (STJP002335)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse ENPP-2/Autotaxin-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Endotoxin: Less than 1EU per Mu g by the LAL method.
Gene Symbol: Enpp2
Gene ID: 18606
Uniprot ID: ENPP2_MOUSE
Immunogen Region: Ser49-Ile862
Immunogen: Recombinant Mouse ENPP-2/Autotaxin Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Ser49-Ile862.
Post Translational Modifications N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity. Secretion requires simultaneous glycosylation on Asn-53 and Asn-410, while probable glycosylation of Asn-410 has a preferential role on lysoPLD activity. Not O-glycosylated. The interdomain disulfide bond between Cys-413 and Cys-805 is essential for catalytic activity.
Function Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Can also act on sphingosylphosphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility-related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development (Probable). Tumor cell motility-stimulating factor. Required for LPA production in activated platelets, cleaves the sn-1 lysophospholipids to generate sn-1 lysophosphatidic acids containing predominantly 18:2 and 20:4 fatty acids. Shows a preference for the sn-1 to the sn-2 isomer of 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF).
Protein Name Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2
E-Npp 2
Autotaxin
Extracellular Lysophospholipase D
Lysopld
Cellular Localisation Secreted
Alternative Protein Names Ectonucleotide Pyrophosphatase/Phosphodiesterase Family Member 2 protein
E-Npp 2 protein
Autotaxin protein
Extracellular Lysophospholipase D protein
Lysopld protein
Enpp2 protein
Npps2 protein
Pdnp2 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号