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  • 产品名称：Mouse Fc-gamma RIV/CD16-2 protein (Recombinant) (C-His) (STJP001383)

  • 产品型号：STJP001383
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse Fc-gamma RIV/CD16-2 protein (Recombinant) (C-His) (STJP001383)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Fc-gamma RIV/CD16-2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: Fcgr4
Gene ID: 246256
Uniprot ID: FCG3A_MOUSE
Immunogen: Recombinant Mouse Fc-gamma RIV/CD16-2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly21-Gln 203) of mouse Fc gamma RIV/CD16-2 (Accession #NP_653142.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications N-glycosylated. Phosphorylated following receptor ligation.
Function Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG). Binds with intermediate affinity to both IgG2a and IgG2b. Can bind to IgG2a and IgG2b monomers. Does not display binding to IgG1 or IgG3. Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection. On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses. Mediates neutrophil activation by IgG complexes redundantly with FCGR2A. Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a. Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE). Binds with low affinity to both the a and b allotypes of IgE. Has also been shown to bind to IgE allotype a only but not to allotype b. Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes. Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions. Mediates enhanced ADCC in response to afucosylated IgGs.
Protein Name Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A
Igg Fc Receptor Iii-A
Cd16-2
Fcgammariv
Cd Antigen Cd16a
Database Links Reactome: R-MMU-163125
Reactome: -MMU-198933
Reactome: -MMU-2029481
Reactome: -MMU-2029482
Reactome: -MMU-2029485
Reactome: -MMU-6798695
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Low Affinity Immunoglobulin Gamma Fc Region Receptor Iii-A protein
Igg Fc Receptor Iii-A protein
Cd16-2 protein
Fcgammariv protein
Cd Antigen Cd16a protein
Fcgr4 protein
Fcgr3a protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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