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  • 产品名称：Human ChT (High Affinity Choline Transporter) Sandwich ELISA Kit (STJE0007948)

  • 产品型号：STJE0007948
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ChT (High Affinity Choline Transporter) Sandwich ELISA Kit (STJE0007948)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.057ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This ChT Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: SLC5A7
Gene ID: 60482
Uniprot ID: SC5A7_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in putamen, spinal cord and medulla. Expressed in cholinergic neurons.
Post Translational Modifications Phosphorylated.
Function High-affinity Na(+)-coupled choline transmembrane symporter. Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry. Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion. Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release. SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials. Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity.
Protein Name High Affinity Choline Transporter 1
Hcht1
Hemicholinium-3-Sensitive Choline Transporter
Cht
Solute Carrier Family 5 Member 7
Database Links Reactome: R-HSA-264642
Reactome: R-HSA-425366
Reactome: R-HSA-5619114
Reactome: R-HSA-5658471
Cellular Localisation Presynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Axon
Early Endosome Membrane
Cytoplasmic Vesicle
Secretory Vesicle
Synaptic Vesicle Membrane
Localized At The Neuromuscular Junction
Localization At The Plasma Membrane Is Transient Due To The Rapid Endocytosis Of Slc5a7/Cht1 Via The Clathrin-Mediated Pathway
Where It Localizes To Early Endosomes
Also Localized To Synaptic Vesicles Where It Is Likely Mobilized To The Cell Surface By Exocytosis
Alternative ELISA Names High Affinity Choline Transporter 1 ELISA kit
Hcht1 ELISA kit
Hemicholinium-3-Sensitive Choline Transporter ELISA kit
Cht ELISA kit
Solute Carrier Family 5 Member 7 ELISA kit
SLC5A7 ELISA kit
CHT1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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