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  • 产品名称：Human CIRBP (Cold-Inducible RNA-Binding Protein) Sandwich ELISA Kit Ready-To-Use (STJE0014328)

  • 产品型号：STJE0014328
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CIRBP (Cold-Inducible RNA-Binding Protein) Sandwich ELISA Kit Ready-To-Use (STJE0014328)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 32.6pg/mL
Detection Limit: 78.1-5000pg/mL
Short Description: This CIRBP Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CIRBP
Gene ID: 1153
Uniprot ID: CIRBP_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: serum, plasma, tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous.
Post Translational Modifications Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs. Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.
Function Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor. Promotes assembly of stress granules (SGs), when overexpressed.
Protein Name Cold-Inducible Rna-Binding Protein
A18 Hnrnp
Glycine-Rich Rna-Binding Protein Cirp
Database Links
Cellular Localisation Nucleus
Nucleoplasm
Cytoplasm
Translocates From The Nucleus To The Cytoplasm After Exposure To Uv Radiation
Translocates From The Nucleus To The Cytoplasm Into Stress Granules Upon Various Cytoplasmic Stresses
Such As Osmotic And Heat Shocks
Its Recruitment Into Stress Granules Occurs In The Absence Of Tiar Proteins
Alternative ELISA Names Cold-Inducible Rna-Binding Protein ELISA kit
A18 Hnrnp ELISA kit
Glycine-Rich Rna-Binding Protein Cirp ELISA kit
CIRBP ELISA kit
A18HNRNP ELISA kit
CIRP ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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