产品详情
查看大图

  • 产品名称：Mouse IFN-beta protein (Recombinant) (C-hFc&His) (STJP001155)

  • 产品型号：STJP001155
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Mouse IFN-beta protein (Recombinant) (C-hFc&His) (STJP001155)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IFN-beta-C-hFc&His protein was developed from hek293 cells and has a target region of C-hFc&His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Recombinant Mouse IFN-beta enhances STAT1 autophosphorylation in Bone-marrow-derived macrophage (BMDM).5-500 ng/mL of Recombinant Mouse IFN-beta can enhance STAT1 autophosphorylation.
Gene Symbol: Ifnb1
Gene ID: 15977
Uniprot ID: IFNB_MOUSE
Immunogen Region: Ile22-Asn182
Immunogen: Active Recombinant Mouse IFN-beta Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile22-Asn182) of mouse Interferon beta (Accession #NP_034640.1) fused with an Fc, 6×His tag at the C-terminus.
Post Translational Modifications This beta interferon does not have a disulfide bond.
Function Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth.
Protein Name Interferon Beta
Ifn-Beta
Database Links Reactome: R-MMU-909733
Reactome: -MMU-912694
Cellular Localisation Secreted
Alternative Protein Names Interferon Beta protein
Ifn-Beta protein
Ifnb1 protein
Ifb protein
Ifnb protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号