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  • 产品名称：Anti-ARSG antibody (376-525) (STJ119309)

  • 产品型号：STJ119309
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARSG antibody (376-525) (STJ119309)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ARSG (376-525) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ARSG
Gene ID: 22901
Uniprot ID: ARSG_HUMAN
Immunogen Region: 376-525
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 376-525 of human ARSG (NP_001254656.1).
Immunogen Sequence: AQASLPQGRRFDGVDVSEVL FGRSQPGHRVLFHPNSGAAG EFGALQTVRLERYKAFYITG GARACDGSTGPELQHKFPLI FNLEDDTAEAVPLERGGAEY QAVLPEVRKVLADVLQDIAN DNISSADYTQDPSVTPCCNP YQIACRCQAA
Tissue Specificity Widely expressed, with very low expression in brain, lung, heart and skeletal muscle.
Post Translational Modifications N-glycosylated. N-glycosylated with both high mannose and complex type sugars. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 63-kDa precursor undergoes proteolytic processing in two steps, yielding two fragments in the first step (apparent molecular masses of 44 and 18 kDa). In the second step, the 44-kDa fragment is processed further to the 34- and 10-kDa chains. The 10-kDa chain is a cleavage product of the 44-kDa fragment but linked to the 18-kDa chain through a disulfide bridge.
Function Displays arylsulfatase activity at acidic pH towards artificial substrates, such as p-nitrocatechol sulfate and also, but with a lower activity towards p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. Catalyzes the hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin.
Protein Name Arylsulfatase G
Asg
N-Sulfoglucosamine-3-Sulfatase
Database Links Reactome: R-HSA-1660662
Reactome: R-HSA-1663150
Cellular Localisation Lysosome
The 63-Kda Precursor Protein Localizes To Pre-Lysosomal Compartments And Tightly Associates With Organelle Membranes
Most Likely The Endoplasmic Reticulum
In Contrast
Proteolytically Processed Fragments Of 34-
18- And 10-Kda Are Found In Lysosomal Fractions And Lose Their Membrane Association
Alternative Antibody Names Anti-Arylsulfatase G antibody
Anti-Asg antibody
Anti-N-Sulfoglucosamine-3-Sulfatase antibody
Anti-ARSG antibody
Anti-KIAA1001 antibody
Anti-UNQ839 antibody
Anti-PRO1777 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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