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  • 产品名称：Mouse IL-33 protein (Recombinant) (C-His) (STJP001968)

  • 产品型号：STJP001968
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse IL-33 protein (Recombinant) (C-His) (STJP001968)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IL-33-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Il33
Gene ID: 77125
Uniprot ID: IL33_MOUSE
Immunogen Region: Ser109-Ile266
Immunogen: Recombinant Mouse IL-33 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser109-Ile266) of mouse IL33 (Accession #NP_598536.2) fused with and a 6×His tag at the C-terminus.
Function Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as an enhancer of polarization of alternatively activated macrophages. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation.
Protein Name Interleukin-33
Il-33 Cleaved Into - Interleukin-33(102-266 - Interleukin-33(109-266
Database Links Reactome: R-MMU-1257604
Reactome: -MMU-5689880
Reactome: -MMU-6811558
Reactome: -MMU-9014843
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Cytoplasmic Vesicle
Secretory Vesicle
Secreted
Secreted And Released In The Extracellular Milieu By Passing Through The Gasdermin-D (Gsdmd) Pore Following Cleavage By Cela1
Associates With Heterochromatin And Mitotic Chromosomes
The Secretion Is Dependent On Protein Unfolding And Facilitated By The Cargo Receptor Tmed10
It Results In Protein Translocation From The Cytoplasm Into The Ergic (Endoplasmic Reticulum-Golgi Intermediate Compartment) Followed By Vesicle Entry And Secretion
(Microbial Infection) Upon Infection With H
Polygyrus
Tethered To The Nucleus By The H
Polygyrus Parasitic Protein Ari
Alternative Protein Names Interleukin-33 protein
Il-33 Cleaved Into - Interleukin-33(102-266 - Interleukin-33(109-266 protein
Il33 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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