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  • 产品名称：SIGLEC10 Blocking Peptide for STJ503026 peptide (STJ504931)

  • 产品型号：STJ504931-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
SIGLEC10 Blocking Peptide for STJ503026 peptide (STJ504931)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: SIGLEC10 Blocking Peptide for STJ503026 is synthetically produced from the 650-697 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: SIGLEC10
Gene ID: 89790
Uniprot ID: SIG10_HUMAN
Immunogen Region: 650-697
Specificity: This blocking peptide is recommended for use in combination with SIGLEC10 antibody, STJ503026
Immunogen: Synthetic peptide taken within amino acid region 650-697 on human SIGLEC10 protein.
Tissue Specificity Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.
Post Translational Modifications Phosphorylation of Tyr-667 is involved in binding to PTPN6.
Function Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1. In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. In association with CD24 may regulate the immune repsonse of natural killer (NK) cells. Plays a role in the control of autoimmunity. During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1, which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification.
Peptide Name Sialic Acid-Binding Ig-Like Lectin 10
Siglec-10
Siglec-Like Protein 2
Database Links Reactome: R-HSA-198933
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cell Membrane
Isoform 3: Cell Membrane
Isoform 4: Cell Membrane
Isoform 5: Secreted
Alternative Peptide Names Sialic Acid-Binding Ig-Like Lectin 10 protein
Siglec-10 protein
Siglec-Like Protein 2 protein
SIGLEC10 protein
SLG2 protein
UNQ477 protein
PRO940 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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