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  • 产品名称：Anti-ASCC2 antibody (STJA0008414)

  • 产品型号：STJA0008414
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ASCC2 antibody (STJA0008414)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Activating signal cointegrator 1 complex subunit 2 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ASCC2
Gene ID: 84164
Uniprot ID: ASCC2_HUMAN
Specificity: This antibody detects endogenous levels of ASCC2 at Human, Mouse
Immunogen: Synthesized peptide derived from human ASCC2
Function Ubiquitin-binding protein involved in DNA repair and rescue of stalled ribosomes. Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains. Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation. Involved in activation of the ribosome quality control (RQC) pathway, a pathway that degrades nascent peptide chains during problematic translation. Specifically recognizes and binds RPS20/uS10 ubiquitinated by ZNF598, promoting recruitment of the RQT (ribosome quality control trigger) complex on stalled ribosomes, followed by disassembly of stalled ribosomes.
Protein Name Activating Signal Cointegrator 1 Complex Subunit 2
Asc-1 Complex Subunit P100
Trip4 Complex Subunit P100
Database Links Reactome: R-HSA-112126
Cellular Localisation Nucleus
Nucleus Speckle
Colocalizes With The Spliceosomal Components Prpf8 And Snrnp200/Brr2 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage
Colocalizes With Rnf113a And 'Lys-63'-Linked Polyubiquitinated Proteins
Alkbh3 And Ascc3 In Nuclear Foci When Cells Have Been Exposed To Alkylating Agents That Cause Dna Damage
Alternative Antibody Names Anti-Activating Signal Cointegrator 1 Complex Subunit 2 antibody
Anti-Asc-1 Complex Subunit P100 antibody
Anti-Trip4 Complex Subunit P100 antibody
Anti-ASCC2 antibody
Anti-ASC1P100 antibody
Anti-RQT3 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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