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  • 产品名称：SPT5 Positive Control peptide (Phospho) (STJ506407)

  • 产品型号：STJ506407-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
SPT5 Positive Control peptide (Phospho) (STJ506407)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Phospho-SPT5 Positive Control is synthetically produced from the 760-810 sequence and is suitable for use in western blot applications.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Supt5h
Gene ID: 20924
Uniprot ID: SPT5H_MOUSE
Immunogen Region: 760-810
Post Translational Modifications Methylated by PRMT1/HRMT1L2 and PRMT5/SKB1. Methylation negatively regulates interaction with P-TEFb and RNA polymerase II. Phosphorylated by CDK7 and CDK9. Phosphorylation by P-TEFb alleviates transcriptional pausing. Phosphorylation may also stimulate interaction with PIN1. Bulk phosphorylation occurs predominantly in mitosis.
Function Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites.
Peptide Name Transcription Elongation Factor Spt5
Drb Sensitivity-Inducing Factor Large Subunit
Dsif Large Subunit
Database Links Reactome: R-MMU-112382
Reactome: -MMU-113418
Reactome: -MMU-674695
Reactome: -MMU-6796648
Reactome: -MMU-6807505
Reactome: -MMU-72086
Reactome: -MMU-75955
Reactome: -MMU-77075
Cellular Localisation Nucleus
Alternative Peptide Names Transcription Elongation Factor Spt5 protein
Drb Sensitivity-Inducing Factor Large Subunit protein
Dsif Large Subunit protein
Supt5h protein
Supt5 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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