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  • 产品名称：NGF protein (STJP000157)

  • 产品型号：STJP000157
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
NGF protein (STJP000157)
详情介绍：
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: NGF-protein was developed from. For use in research applications.
Formulation: PBS pH 7.4
Purification: Purified by ion-exchange chromatography and gel-filtration from serum-free CHO growth media. Protein is sterile-filtrated through 0.22 µm filter
Concentration: 1 mg/ml
Storage Instruction: Store at-70°C upon receipt. Recommended to aliquot into smaller quantities. Avoid repeated freeze-thaw cycles
Gene Symbol: NGF
Gene ID: 4803
Uniprot ID: NGF_HUMAN
Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.
Protein Name Beta-Nerve Growth Factor
Beta-Ngf
Database Links Reactome: R-HSA-167021
Reactome: R-HSA-167044
Reactome: R-HSA-167060
Reactome: R-HSA-170968
Reactome: R-HSA-170984
Reactome: R-HSA-177504
Reactome: R-HSA-187042
Reactome: R-HSA-187706
Reactome: R-HSA-193648
Reactome: R-HSA-193670
Reactome: R-HSA-193681
Reactome: R-HSA-198203
Reactome: R-HSA-198745
Reactome: R-HSA-205017
Reactome: R-HSA-205025
Reactome: R-HSA-205043
Reactome: R-HSA-209543
Reactome: R-HSA-209560
Reactome: R-HSA-209563
Cellular Localisation Secreted
Endosome Lumen
Prongf Is Endocytosed After Binding To The Cell Surface Receptor Formed By Sort1 And Ngfr
Alternative Protein Names Beta-Nerve Growth Factor protein
Beta-Ngf protein
NGF protein
NGFB protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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