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  • 产品名称：TICAM2 Positive Control for STJ503386 peptide (STJ505283)

  • 产品型号：STJ505283-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
TICAM2 Positive Control for STJ503386 peptide (STJ505283)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TICAM2 Positive Control for STJ503386 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500-1:750
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TICAM2
Gene ID: 100302736/353376
Uniprot ID: TCAM2_HUMAN
Specificity: This is positive control is recommended for use in combination with TICAM2 antibody STJ503386.
Tissue Specificity Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1).
Post Translational Modifications Phosphorylated by PRKCE in response to LPS. Phosphorylation is essential for its function. It is depleted from the membrane upon phosphorylation. Tyrosine phosphorylation is inhibited by phosphatase PTPN4. Isoform 1 is myristoylated. Required for membrane association which is critical for its ability to initiate efficient signaling.
Function Functions as sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction. In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement. Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response. Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria. Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.
Peptide Name Tir Domain-Containing Adapter Molecule 2
Ticam-2
Putative Nf-Kappa-B-Activating Protein 502
Trif-Related Adapter Molecule
Toll-Like Receptor Adaptor Protein 3
Toll/Interleukin-1 Receptor Domain-Containing Protein
Myd88-4
Database Links Reactome: R-HSA-140534
Reactome: R-HSA-166016
Reactome: R-HSA-166166
Reactome: R-HSA-2562578
Reactome: R-HSA-6798695
Reactome: R-HSA-936964
Reactome: R-HSA-937041
Reactome: R-HSA-937072
Reactome: R-HSA-975163
Cellular Localisation Isoform 1: Cytoplasm
Golgi Apparatus
Cell Membrane
Endoplasmic Reticulum
Early Endosome Membrane
Late Endosome Membrane
Cell Projection
Phagocytic Cup
Localized To The Plasma Membrane As A Result Of Myristoylation
Phosphorylation On Ser-16 Leads To Its Depletion From The Membrane
Upon Lps Stimulation Colcoalizes With Isoform 2 In Late Endosomes
Isoform 2: Endoplasmic Reticulum
Translocates To Late Endosomes Upon Lps Stimulation Where It Colcoalizes With Isoform 1
Alternative Peptide Names Tir Domain-Containing Adapter Molecule 2 protein
Ticam-2 protein
Putative Nf-Kappa-B-Activating Protein 502 protein
Trif-Related Adapter Molecule protein
Toll-Like Receptor Adaptor Protein 3 protein
Toll/Interleukin-1 Receptor Domain-Containing Protein protein
Myd88-4 protein
TICAM2 protein
TIRAP3 protein
TIRP protein
TRAM protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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