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  • 产品名称：Anti-ATIC antibody (STJ98509)

  • 产品型号：STJ98509
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATIC antibody (STJ98509)
详情介绍：
Host: Mouse
Applications: WB
Reactivity: Human/Rabbit
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Bifunctional purine biosynthesis protein ATIC is suitable for use in Western Blot research applications.
Clonality: Monoclonal
Conjugation: Unconjugated
Formulation: Liquid in 0.1M Tris-Glycine (pH7.4, 150 mM NaCl) , 0.2% Sodium Azide and 50% Glycerol.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATIC
Gene ID: 471
Uniprot ID: PUR9_HUMAN
Specificity: IMP cyclohydrolase Monoclonal Antibody detects endogenous levels of IMP cyclohydrolase protein.
Immunogen: Purified recombinant human IMP cyclohydrolase protein fragments expressed in E.coli.
Function Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization.
Protein Name Bifunctional Purine Biosynthesis Protein Atic
Aicar Transformylase/Inosine Monophosphate Cyclohydrolase
Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase
5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase
Aicar Formyltransferase
Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase
Imp Cyclohydrolase
Imp Synthase
Inosinicase
Database Links Reactome: R-HSA-73817
Reactome: R-HSA-9725370
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Bifunctional Purine Biosynthesis Protein Atic antibody
Anti-Aicar Transformylase/Inosine Monophosphate Cyclohydrolase antibody
Anti-Atic Cleaved Into - Bifunctional Purine Biosynthesis Protein Atic - N-Terminally Processed Includes - Phosphoribosylaminoimidazolecarboxamide Formyltransferase antibody
Anti-5-Aminoimidazole-4-Carboxamide Ribonucleotide Formyltransferase antibody
Anti-Aicar Formyltransferase antibody
Anti-Aicar Transformylase - Inosine 5'-Monophosphate Cyclohydrolase antibody
Anti-Imp Cyclohydrolase antibody
Anti-Imp Synthase antibody
Anti-Inosinicase antibody
Anti-ATIC antibody
Anti-PURH antibody
Anti-OK antibody
Anti-SW-cl.86 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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