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  • 产品名称：Anti-ATP11C antibody (430-650) (STJ119043)

  • 产品型号：STJ119043
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATP11C antibody (430-650) (STJ119043)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP11C (430-650) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP11C
Gene ID: 286410
Uniprot ID: AT11C_HUMAN
Immunogen Region: 430-650
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 430-650 of human ATP11C (NP_775965.2).
Immunogen Sequence: DGHKYKGVTQEVDGLSQTDG TLTYFDKVDKNREELFLRAL CLCHTVEIKTNDAVDGATES AELTYISSSPDEIALVKGAK RYGFTFLGNRNGYMRVENQR KEIEEYELLHTLNFDAVRRR MSVIVKTQEGDILLFCKGAD SAVFPRVQNHEIELTKVHVE RNAMDGYRTLCVAFKEIAPD DYERINRQLIEAKMALQDRE EKMEKVFDDIETNMNLIGAT A
Tissue Specificity Widely expressed.
Post Translational Modifications Proteolytically cleaved by CASP3, CASP6 and CASP7. Phosphorylated at Ser-1116 likely by PRKCA.this creates a functional di-leucine motif that is sufficient for endocytosis.
Function Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane. Major PS-flippase in immune cell subsets. In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages. Required for B cell differentiation past the pro-B cell stage. Seems to mediate PS flipping in pro-B cells. May be involved in the transport of cholestatic bile acids.
Protein Name Phospholipid-Transporting Atpase Ig
Atpase Iq
Atpase Class Vi Type 11c
P4-Atpase Flippase Complex Alpha Subunit Atp11c
Database Links Reactome: R-HSA-936837
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Early Endosome Membrane
Recycling Endosome Membrane
Efficient Exit From The Endoplasmic Reticulum Requires The Presence Of Tmem30a
Internalized Via Clathrin-Dependent Endocytosis In Response To Ca(2+) Signaling Induced By G-Protein Coupled Serotonin And Histamine Receptors
Alternative Antibody Names Anti-Phospholipid-Transporting Atpase Ig antibody
Anti-Atpase Iq antibody
Anti-Atpase Class Vi Type 11c antibody
Anti-P4-Atpase Flippase Complex Alpha Subunit Atp11c antibody
Anti-ATP11C antibody
Anti-ATPIG antibody
Anti-ATPIQ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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