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  • 产品名称：Anti-Ankyrin 1/ANK1 antibody (C-Term) (STJ71553)

  • 产品型号：STJ71553-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-Ankyrin 1/ANK1 antibody (C-Term) (STJ71553)
详情介绍：
Host: Goat
Applications: Pep-ELISA
Reactivity: Human/Mouse/Rat/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Ankyrin 1/ANK1 (C-Term) is suitable for use in ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ANK1
Gene ID: 286
Uniprot ID: ANK1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_000028.3; NP_065208.2; NP_065209.2; NP_065210.2; NP_065211.2; NP_065213.2
Specificity: This antibody is expected to recognise isoform 3 (NP_000028.3) and isoform 5 (NP_065211.2).
Immunogen Sequence: QIVKRASLKRGKQ
Post Translational Modifications Regulated by phosphorylation. Palmitoylated. Hydroxylated by HIF1AN at several asparagine and 1 aspartate residue within ANK repeat region. Hydroxylation seems to increase the conformational stability of this region and may also modulate protein-protein interactions mediated by the ANK repeat region. (Microbial infection) Probably cleaved by P.falciparum SERA6.the cleavage probably causes the disruption of the actin cytoskeleton and the rupture of the erythrocyte cell membrane releasing the merozoites.
Function Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane. Attaches integral membrane proteins to cytoskeletal elements.binds to the erythrocyte membrane protein band 4.2, to Na-K ATPase, to the lymphocyte membrane protein GP85, and to the cytoskeletal proteins fodrin, tubulin, vimentin and desmin. Erythrocyte ankyrins also link spectrin (beta chain) to the cytoplasmic domain of the erythrocytes anion exchange protein.they retain most or all of these binding functions. Isoform Mu17: Together with obscurin in skeletal muscle may provide a molecular link between the sarcoplasmic reticulum and myofibrils.
Protein Name Ankyrin-1
Ank-1
Ankyrin-R
Erythrocyte Ankyrin
Database Links Reactome: R-HSA-445095
Reactome: R-HSA-447038
Reactome: R-HSA-447041
Reactome: R-HSA-447043
Reactome: R-HSA-6807878
Cellular Localisation Isoform Er1: Cytoplasm
Cytoskeleton
Probably The Other Erythrocyte (Er) Isoforms
Are Located Near The Surface Of Erythrocytic Plasma Membrane
Isoform Mu17: Membrane
Cytoplasm
Myofibril
Sarcomere
M Line
Colocalizes With Obscn Isoform 3/Obscurin At The M Line In Differentiated Skeletal Muscle Cells
Isoform Mu18: Sarcoplasmic Reticulum
Isoform Mu19: Sarcoplasmic Reticulum
Isoform Mu20: Sarcoplasmic Reticulum
Alternative Antibody Names Anti-Ankyrin-1 antibody
Anti-Ank-1 antibody
Anti-Ankyrin-R antibody
Anti-Erythrocyte Ankyrin antibody
Anti-ANK1 antibody
Anti-ANK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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