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  • 产品名称：Human CXADR (Coxsackie Virus And Adenovirus Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0014656)

  • 产品型号：STJE0014656
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CXADR (Coxsackie Virus And Adenovirus Receptor) Sandwich ELISA Kit Ready-To-Use (STJE0014656)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.065ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This CXADR Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: CXADR
Gene ID: 1525
Uniprot ID: CXAR_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy.
Post Translational Modifications N-glycosylated. Palmitoylated on Cys-259 and/or Cys-260.required for proper localization to the plasma membrane.
Function Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6.
Protein Name Coxsackievirus And Adenovirus Receptor
Car
Hcar
Cvb3-Binding Protein
Coxsackievirus B-Adenovirus Receptor
Hcvadr
Database Links Reactome: R-HSA-198933
Reactome: R-HSA-202733
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Basolateral Cell Membrane
Cell Junction
Tight Junction
Adherens Junction
In Epithelial Cells Localizes To The Apical Junction Complex Composed Of Tight And Adherens Junctions
In Airway Epithelial Cells Localized To Basolateral Membrane But Not To Apical Surface
Isoform 3: Secreted
Isoform 4: Secreted
Isoform 5: Secreted
Alternative ELISA Names Coxsackievirus And Adenovirus Receptor ELISA kit
Car ELISA kit
Hcar ELISA kit
Cvb3-Binding Protein ELISA kit
Coxsackievirus B-Adenovirus Receptor ELISA kit
Hcvadr ELISA kit
CXADR ELISA kit
CAR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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