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  • 产品名称：Human CXCL12 (CXCL12) Sandwich ELISA Kit (STJE0000112)

  • 产品型号：STJE0000112-96
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human CXCL12 (CXCL12) Sandwich ELISA Kit (STJE0000112)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.051 ng/mL
Detection Limit: 0156-10 ng/mL
Short Description: This CXCL12 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Conjugation: Biotin
Storage Instruction: Unopened kits can be stored at 2-8°C for 1 year, and opened products must be used within 1 month.
Assay Time: 4 hours
Detection: Colorimetric
Gene Symbol: CXCL12
Gene ID: 6387
Uniprot ID: SDF1_HUMAN
Sample Type: serum, plasma, cell culture supernates, cell lysates, tissue homogenates and other biological fluids
Tissue Specificity Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.
Post Translational Modifications Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.
Function Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development.required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells.
Protein Name Stromal Cell-Derived Factor 1
Sdf-1
Hsdf-1
C-X-C Motif Chemokine 12
Intercrine Reduced In Hepatomas
Irh
Hirh
Pre-B Cell Growth-Stimulating Factor
Pbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-376176
Reactome: R-HSA-380108
Reactome: R-HSA-418594
Reactome: R-HSA-9018519
Cellular Localisation Secreted
Alternative ELISA Names Stromal Cell-Derived Factor 1 ELISA kit
Sdf-1 ELISA kit
Hsdf-1 ELISA kit
C-X-C Motif Chemokine 12 ELISA kit
Intercrine Reduced In Hepatomas ELISA kit
Irh ELISA kit
Hirh ELISA kit
Pre-B Cell Growth-Stimulating Factor ELISA kit
Pbsf Cleaved Into - Sdf-1-Beta(3-72 - Sdf-1-Alpha(3-67 ELISA kit
CXCL12 ELISA kit
SDF1 ELISA kit
SDF1A ELISA kit
SDF1B ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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