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  • 产品名称：TLR7 Positive Control for STJ503281 peptide (STJ505210)

  • 产品型号：STJ505210-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
TLR7 Positive Control for STJ503281 peptide (STJ505210)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TLR7 Positive Control for STJ503281 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TLR7
Gene ID: 51284
Uniprot ID: TLR7_HUMAN
Specificity: This is positive control is recommended for use in combination with TLR7 antibody STJ503281.
Tissue Specificity Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. Expressed in peripheral mononuclear blood cells.
Function Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively.
Peptide Name Toll-Like Receptor 7
Database Links Reactome: R-HSA-1679131
Reactome: R-HSA-168181
Reactome: R-HSA-9679191
Reactome: R-HSA-9692916
Reactome: R-HSA-9705671
Reactome: R-HSA-975110
Reactome: R-HSA-975138
Reactome: R-HSA-975155
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endosome
Lysosome
Cytoplasmic Vesicle
Phagosome
Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist
Alternative Peptide Names Toll-Like Receptor 7 protein
TLR7 protein
UNQ248 protein
PRO285 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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