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  • 产品名称：TLR9 Blocking Peptide for STJ503282 peptide (STJ505009)

  • 产品型号：STJ505009-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
TLR9 Blocking Peptide for STJ503282 peptide (STJ505009)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TLR9 Blocking Peptide for STJ503282 is synthetically produced from the 430-460 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: TLR9
Gene ID: 54106
Uniprot ID: TLR9_HUMAN
Immunogen Region: 430-460
Specificity: This blocking peptide is recommended for use in combination with TLR9 antibody, STJ503282
Immunogen: Synthetic peptide taken within amino acid region 430-460 on human TLR9 protein.
Tissue Specificity Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Post Translational Modifications Activated by proteolytic cleavage of the flexible loop between repeats LRR14 and LRR15 within the ectodomain. Cleavage requires UNC93B1. Proteolytically processed by first removing the majority of the ectodomain by either asparagine endopeptidase (AEP) or a cathepsin followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling.
Function Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production.
Peptide Name Toll-Like Receptor 9
Cd Antigen Cd289
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1679131
Reactome: R-HSA-168138
Reactome: R-HSA-9679191
Reactome: R-HSA-975110
Reactome: R-HSA-975138
Reactome: R-HSA-975155
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type I Membrane Protein
Endosome
Lysosome
Cytoplasmic Vesicle
Phagosome
Relocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist
Exit From The Er Requires Unc93b1
Endolysosomal Localization Is Required For Proteolytic Cleavage And Subsequent Activation
Intracellular Localization Of The Active Receptor May Prevent From Responding To Self Nucleic Acid
Alternative Peptide Names Toll-Like Receptor 9 protein
Cd Antigen Cd289 protein
TLR9 protein
UNQ5798 protein
PRO19605 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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