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  • 产品名称：Anti-ATP2B2 antibody (250-330 aa) (STJ191166)

  • 产品型号：STJ191166
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATP2B2 antibody (250-330 aa) (STJ191166)
详情介绍：
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Plasma membrane calcium-transporting ATPase 2 (250-330 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP2B2
Gene ID: 491
Uniprot ID: AT2B2_HUMAN
Immunogen Region: 250-330 aa
Specificity: AT2B2 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 250-330
Function ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels in specialized cells of cerebellar circuit and vestibular and cochlear systems. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment. Has fast activation and Ca(2+) clearance rate suited to control fast neuronal Ca(2+) dynamics. At parallel fiber to Purkinje neuron synapse, mediates presynaptic Ca(2+) efflux in response to climbing fiber-induced Ca(2+) rise. Provides for fast return of Ca(2+) concentrations back to their resting levels, ultimately contributing to long-term depression induction and motor learning. Plays an essential role in hearing and balance. In cochlear hair cells, shuttles Ca(2+) ions from stereocilia to the endolymph and dissipates Ca(2+) transients generated by the opening of the mechanoelectrical transduction channels. Regulates Ca(2+) levels in the vestibular system, where it contributes to the formation of otoconia. In non-excitable cells, regulates Ca(2+) signaling through spatial control of Ca(2+) ions extrusion and dissipation of Ca(2+) transients generated by store-operated channels. In lactating mammary gland, allows for the high content of Ca(2+) ions in the milk.
Protein Name Plasma Membrane Calcium-Transporting Atpase 2
Pmca2
Plasma Membrane Calcium Atpase Isoform 2
Plasma Membrane Calcium Pump Isoform 2
Database Links Reactome: R-HSA-418359
Reactome: R-HSA-5578775
Reactome: R-HSA-936837
Reactome: R-HSA-9662360 Q01814-2
Reactome: R-HSA-9662361 Q01814-2
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Synapse
Isoform Wa: Apical Cell Membrane
Basolateral Cell Membrane
Isoform Wb: Apical Cell Membrane
Isoform Xb: Basolateral Cell Membrane
Isoform Za: Basolateral Cell Membrane
Isoform Zb: Basolateral Cell Membrane
Alternative Antibody Names Anti-Plasma Membrane Calcium-Transporting Atpase 2 antibody
Anti-Pmca2 antibody
Anti-Plasma Membrane Calcium Atpase Isoform 2 antibody
Anti-Plasma Membrane Calcium Pump Isoform 2 antibody
Anti-ATP2B2 antibody
Anti-PMCA2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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