产品详情
查看大图

  • 产品名称：TREM2 Blocking Peptide for STJ506376 peptide (STJ506377)

  • 产品型号：STJ506377-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
TREM2 Blocking Peptide for STJ506376 peptide (STJ506377)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: TREM2 Blocking Peptide for STJ506376 is synthetically produced from the 100-200 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: KL
Gene ID: 9365
Uniprot ID: KLOT_HUMAN
Immunogen Region: 100-200
Specificity: This blocking peptide is recommended for use in combination with TREM2 antibody, STJ506376
Tissue Specificity Present in cortical renal tubules (at protein level). Soluble peptide is present in serum and cerebrospinal fluid. Expressed in kidney, placenta, small intestine and prostate. Down-regulated in renal cell carcinomas, hepatocellular carcinomas, and in chronic renal failure kidney.
Post Translational Modifications N-glycosylated.
Function May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D. Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Peptide Name Klotho Cleaved Into - Klotho Peptide
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-190374
Reactome: R-HSA-2219530
Reactome: R-HSA-5654219
Reactome: R-HSA-5654687
Reactome: R-HSA-5654688
Reactome: R-HSA-5654689
Reactome: R-HSA-5654693
Reactome: R-HSA-5654726
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Apical Cell Membrane
Isoform 1 Shedding Leads To A Soluble Peptide
Isoform 2: Secreted
Klotho Peptide: Secreted
Alternative Peptide Names Klotho Cleaved Into - Klotho Peptide protein
KL protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号