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  • 产品名称：Anti-ATP4B antibody (62-291) (STJ112145)

  • 产品型号：STJ112145
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATP4B antibody (62-291) (STJ112145)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP4B (62-291) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP4B
Gene ID: 496
Uniprot ID: ATP4B_HUMAN
Immunogen Region: 62-291
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 62-291 of human ATP4B (NP_000696.1).
Immunogen Sequence: LMQTVDPYTPDYQDQLRSPG VTLRPDVYGEKGLEIVYNVS DNRTWADLTQTLHAFLAGYS PAAQEDSINCTSEQYFFQES FRAPNHTKFSCKFTADMLQN CSGLADPNFGFEEGKPCFII KMNRIVKFLPSNGSAPRVDC AFLDQPRELGQPLQVKYYPP NGTFSLHYFPYYGKKAQPHY SNPLVAAKLLNIPRNAEVAI VCKVMAEHVTFNNPHDPYEG KVEFKLKIEK
Post Translational Modifications N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane.
Function The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump. Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle.
Protein Name Potassium-Transporting Atpase Subunit Beta
Gastric H(+/K(+ Atpase Subunit Beta
Proton Pump Beta Chain
Database Links Reactome: R-HSA-936837
Cellular Localisation Apical Cell Membrane
Single-Pass Type Ii Membrane Protein
Cell Membrane
Localized In The Apical Canalicular Membrane Of Parietal Cells
Alternative Antibody Names Anti-Potassium-Transporting Atpase Subunit Beta antibody
Anti-Gastric H(+/K(+ Atpase Subunit Beta antibody
Anti-Proton Pump Beta Chain antibody
Anti-ATP4B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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