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  • 产品名称：Visfatin Blocking Peptide peptide (STJ505066)

  • 产品型号：STJ505066-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Visfatin Blocking Peptide peptide (STJ505066)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Visfatin Blocking Peptide is synthetically produced from the 400-490 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Dilution Range: WB:
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NAMPT
Gene ID: 10135
Uniprot ID: NAMPT_HUMAN
Immunogen Region: 400-490
Immunogen: C-epitope synthetic peptide taken within amino acid region 400-490 on human Visfatin protein
Tissue Specificity Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Function Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression.
Peptide Name Nicotinamide Phosphoribosyltransferase
Namprtase
Nampt
Pre-B-Cell Colony-Enhancing Factor 1
Pre-B Cell-Enhancing Factor
Visfatin
Database Links Reactome: R-HSA-1368108
Reactome: R-HSA-197264
Reactome: R-HSA-9768919
Cellular Localisation Nucleus
Cytoplasm
Secreted
Under Non-Inflammatory Conditions
Visfatin Predominantly Exhibits A Granular Pattern Within The Nucleus
Secreted By Endothelial Cells Upon Il-1beta Stimulation
Abundantly Secreted In Milk
Reaching 100-Fold Higher Concentrations Compared To Maternal Serum
Alternative Peptide Names Nicotinamide Phosphoribosyltransferase protein
Namprtase protein
Nampt protein
Pre-B-Cell Colony-Enhancing Factor 1 protein
Pre-B Cell-Enhancing Factor protein
Visfatin protein
NAMPT protein
PBEF protein
PBEF1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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