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  • 产品名称：Anti-ATP7A antibody (591-640 aa) (STJ91776)

  • 产品型号：STJ91776
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ATP7A antibody (591-640 aa) (STJ91776)
详情介绍：
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Copper-transporting ATPase 1 (591-640 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC 1:100-1:300
ELISA 1:40000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ATP7A
Gene ID: 538
Uniprot ID: ATP7A_HUMAN
Immunogen Region: 591-640 aa
Specificity: ATP7A Polyclonal Antibody detects endogenous levels of ATP7A protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ATP7A at the amino acid range 591-640
Function ATP-driven copper (Cu(+)) ion pump that plays an important role in intracellular copper ion homeostasis. Within a catalytic cycle, acquires Cu(+) ion from donor protein on the cytoplasmic side of the membrane and delivers it to acceptor protein on the lumenal side. The transfer of Cu(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation that shifts the pump conformation from inward-facing to outward-facing state. Under physiological conditions, at low cytosolic copper concentration, it is localized at the trans-Golgi network (TGN) where it transfers Cu(+) ions to cuproenzymes of the secretory pathway. Upon elevated cytosolic copper concentrations, it relocalizes to the plasma membrane where it is responsible for the export of excess Cu(+) ions. May play a dual role in neuron function and survival by regulating cooper efflux and neuronal transmission at the synapse as well as by supplying Cu(+) ions to enzymes such as PAM, TYR and SOD3. In the melanosomes of pigmented cells, provides copper cofactor to TYR to form an active TYR holoenzyme for melanin biosynthesis.
Protein Name Copper-Transporting Atpase 1
Copper Pump 1
Menkes Disease-Associated Protein
Database Links Reactome: R-HSA-3299685
Reactome: R-HSA-6803544
Reactome: R-HSA-936837
Cellular Localisation Golgi Apparatus
Trans-Golgi Network Membrane
Multi-Pass Membrane Protein
Cell Membrane
Melanosome Membrane
Early Endosome Membrane
Cell Projection
Axon
Dendrite
Postsynaptic Density
Cycles Constitutively Between The Tgn And The Plasma Membrane
Predominantly Found In The Tgn And Relocalized To The Plasma Membrane In Response To Elevated Copper Levels
Targeting Into Melanosomes Is Regulated By Bloc-1 Complex
In Response To Glutamate
Translocates To Neuron Processes With A Minor Fraction At Extrasynaptic Sites
Isoform 3: Cytoplasm
Cytosol
Isoform 5: Endoplasmic Reticulum
Alternative Antibody Names Anti-Copper-Transporting Atpase 1 antibody
Anti-Copper Pump 1 antibody
Anti-Menkes Disease-Associated Protein antibody
Anti-ATP7A antibody
Anti-MC1 antibody
Anti-MNK antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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