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  • 产品名称：Anti-AOF2/LSD1 antibody (Internal) (STJ73308)

  • 产品型号：STJ73308-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AOF2/LSD1 antibody (Internal) (STJ73308)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Cow/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-AOF2/LSD1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.5-1.5µg/ml
ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: KDM1A
Gene ID: 23028
Uniprot ID: KDM1A_HUMAN
Immunogen Region: Internal
Accession Number: NP_055828.2
Immunogen Sequence: KHWDQDDDFEFTGSH
Post Translational Modifications Polyubiquitinated by JADE2.which leads to its proteasomal degradation. Deubiquitinated by USP38.preventing it from degradation by the 26S proteasome.
Function Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Effector of SNAI1-mediated transcription repression of E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7.
Protein Name Lysine-Specific Histone Demethylase 1a
Braf35-Hdac Complex Protein Bhc110
Flavin-Containing Amine Oxidase Domain-Containing Protein 2
Histone H3-Dimethyl-L-Lysine(4 Fad-Dependent Demethylase 1a
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-3214842
Reactome: R-HSA-5625886
Reactome: R-HSA-8943724
Reactome: R-HSA-9018519
Reactome: R-HSA-9029569
Reactome: R-HSA-9679191
Reactome: R-HSA-983231
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Lysine-Specific Histone Demethylase 1a antibody
Anti-Braf35-Hdac Complex Protein Bhc110 antibody
Anti-Flavin-Containing Amine Oxidase Domain-Containing Protein 2 antibody
Anti-Histone H3-Dimethyl-L-Lysine(4 Fad-Dependent Demethylase 1a antibody
Anti-KDM1A antibody
Anti-AOF2 antibody
Anti-KDM1 antibody
Anti-KIAA0601 antibody
Anti-LSD1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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