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  • 产品名称：WWOX 1 + 4 Positive Control for STJ503538 peptide (STJ505285)

  • 产品型号：STJ505285-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
WWOX 1 + 4 Positive Control for STJ503538 peptide (STJ505285)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: WWOX 1 + 4 Positive Control for STJ503538 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: WWOX
Gene ID: 51741
Uniprot ID: WWOX_HUMAN
Specificity: This is positive control is recommended for use in combination with WWOX 1 + 4 antibody STJ503538.
Tissue Specificity Widely expressed. Strongly expressed in testis, prostate, and ovary. Overexpressed in cancer cell lines. Isoform 5 and isoform 6 may only be expressed in tumor cell lines.
Post Translational Modifications Phosphorylated upon genotoxic stress. Phosphorylation of Tyr-33 regulates interaction with TP53, TP73 and MAPK8. May also regulate proapoptotic activity. Phosphorylation by TNK2 is associated with polyubiquitination and degradation. Ubiquitinated when phosphorylated by TNK2, leading to its degradation.
Function Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.
Peptide Name Ww Domain-Containing Oxidoreductase
Fragile Site Fra16d Oxidoreductase
Short Chain Dehydrogenase/Reductase Family 41c Member 1
Database Links Reactome: R-HSA-1251985
Reactome: R-HSA-8866904
Reactome: R-HSA-8866907
Cellular Localisation Cytoplasm
Nucleus
Mitochondrion
Golgi Apparatus
Lysosome
Partially Localizes To The Mitochondria
Translocates To The Nucleus Upon Genotoxic Stress Or Tnf Stimulation
Translocates To The Nucleus In Response To Tgfb1
Isoform 5 And Isoform 6 May Localize In The Nucleus
Localized To The Lysosome Probably Upon Binding To Vopp1
Alternative Peptide Names Ww Domain-Containing Oxidoreductase protein
Fragile Site Fra16d Oxidoreductase protein
Short Chain Dehydrogenase/Reductase Family 41c Member 1 protein
WWOX protein
FOR protein
SDR41C1 protein
WOX1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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