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  • 产品名称：ZIP Kinase Positive Control for STJ500733 peptide (STJ505699)

  • 产品型号：STJ505699-5
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
ZIP Kinase Positive Control for STJ500733 peptide (STJ505699)
详情介绍：
Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: ZIP Kinase Positive Control for STJ500733 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Dapk3
Gene ID: 13144
Uniprot ID: DAPK3_MOUSE
Specificity: This is positive control is recommended for use in combination with ZIP Kinase antibody STJ500733.
Immunogen: Purified Death-associated protein kinase 3 protein.
Tissue Specificity Highly expressed in heart, brain, lung, skeletal muscle, kidney and testis. Lower levels in liver and spleen.
Post Translational Modifications Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus. The phosphorylation status is critical for kinase activity, oligomerization and intracellular localization. Phosphorylation at Thr-180, Thr-225 and Thr-265 is essential for activity. The phosphorylated form is localized in the cytoplasm and nuclear translocation or retention is maximal when it is not phosphorylated. Phosphorylation increases the trimeric form, and its dephosphorylation favors a kinase-inactive monomeric form.
Function Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription, translation and actin cytoskeleton reorganization. Regulates both type I (caspase-dependent) apoptotic and type II (caspase-independent) autophagic cell deaths signal, depending on the cellular setting. Involved in formation of promyelocytic leukemia protein nuclear body (PML-NB). Involved in apoptosis involving PAWR which mediates cytoplasmic relocation.in vitro phosphorylates PAWR. Phosphorylates MYL12B in non-muscle cells leading to reorganization of actin cytoskeleton such as in regulation of cell polarity and cell migration. Positively regulates canonical Wnt/beta-catenin signaling through interaction with NLK and TCF7L2.disrupts the NLK-TCF7L2 complex thereby influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates STAT3 and enhances its transcriptional activity. Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, RPL13A association with the GAIT complex and its subsequent involvement in transcript-selective translation inhibition.
Peptide Name Death-Associated Protein Kinase 3
Dap Kinase 3
Dap-Like Kinase
Dlk
Mypt1 Kinase
Zip-Kinase
Cellular Localisation Nucleus
Pml Body
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Chromosome
Centromere
Predominantly Localized To The Nucleus
Relocates To The Cytoplasm On Binding Pawr Where The Complex Appears To Interact With Actin Filaments
Associated With The Centrosomes Throughout The Mitotic Cell Cycle
With The Centromeres From Prophase To Anaphase And With The Contractile Ring During Cytokinesis
Alternative Peptide Names Death-Associated Protein Kinase 3 protein
Dap Kinase 3 protein
Dap-Like Kinase protein
Dlk protein
Mypt1 Kinase protein
Zip-Kinase protein
Dapk3 protein
Zipk protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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