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  • 产品名称：Anti-AXIN2 antibody (800-843) (STJ500195)

  • 产品型号：STJ500195-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-AXIN2 antibody (800-843) (STJ500195)
详情介绍：
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AXIN2 (800-843) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: AXIN2
Gene ID: 8313
Uniprot ID: AXIN2_HUMAN
Immunogen Region: 800-843
Immunogen: Synthetic peptide taken within amino acid region 800-843 on human Axin 2 protein.
Tissue Specificity Expressed in brain and lymphoblast.
Post Translational Modifications Probably phosphorylated by GSK3B and dephosphorylated by PP2A. ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.
Function Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Protein Name Axin-2
Axin-Like Protein
Axil
Axis Inhibition Protein 2
Conductin
Database Links Reactome: R-HSA-201681
Reactome: R-HSA-4411364
Reactome: R-HSA-4641257
Reactome: R-HSA-5689880
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Axin-2 antibody
Anti-Axin-Like Protein antibody
Anti-Axil antibody
Anti-Axis Inhibition Protein 2 antibody
Anti-Conductin antibody
Anti-AXIN2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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