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  • 产品名称：Human DNMT3A (DNA Methyltransferase 3A) Sandwich ELISA Kit Ready-To-Use (STJE0014861)

  • 产品型号：STJE0014861
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human DNMT3A (DNA Methyltransferase 3A) Sandwich ELISA Kit Ready-To-Use (STJE0014861)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.059ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This DNMT3A Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: DNMT3A
Gene ID: 1788
Uniprot ID: DNM3A_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Post Translational Modifications Sumoylated.sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. Auto-methylated at Cys-710: auto-methylation takes place in absence of DNA substrate and inactivates the DNA methyltransferase activity. Inactivation by auto-methylation may be used to inactivate unused DNA methyltransferases in the cell.
Function Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. Also has weak auto-methylation activity on Cys-710 in absence of DNA.
Protein Name Dna
Cytosine-5-Methyltransferase 3a
Dnmt3a
Cysteine Methyltransferase Dnmt3a
Dna Methyltransferase Hsaiiia
Dna Mtase Hsaiiia
M.hsaiiia
Database Links Reactome: R-HSA-212300
Reactome: R-HSA-3214858
Reactome: R-HSA-4655427
Reactome: R-HSA-5334118
Reactome: R-HSA-9710421
Cellular Localisation Nucleus
Chromosome
Cytoplasm
Accumulates In The Major Satellite Repeats At Pericentric Heterochromatin
Alternative ELISA Names Dna ELISA kit
Cytosine-5-Methyltransferase 3a ELISA kit
Dnmt3a ELISA kit
Cysteine Methyltransferase Dnmt3a ELISA kit
Dna Methyltransferase Hsaiiia ELISA kit
Dna Mtase Hsaiiia ELISA kit
M.hsaiiia ELISA kit
DNMT3A ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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