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  • 产品名称：Human EIF6 (Eukaryotic Translation Initiation Factor 6) Sandwich ELISA Kit (STJE0008609)

  • 产品型号：STJE0008609
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human EIF6 (Eukaryotic Translation Initiation Factor 6) Sandwich ELISA Kit (STJE0008609)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.123ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This EIF6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: EIF6
Gene ID: 3692
Uniprot ID: IF6_HUMAN
Sample Type: tissue homogenates, cell lysates or other biological fluids.
Tissue Specificity Expressed at very high levels in colon carcinoma with lower levels in normal colon and ileum and lowest levels in kidney and muscle (at protein level).
Post Translational Modifications Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. Ufmylated by UFL1.
Function Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity. In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis. Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC. Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth.
Protein Name Eukaryotic Translation Initiation Factor 6
Eif-6
B(2gcn Homolog
B4 Integrin Interactor
Cab
P27(Bbp
Database Links
Cellular Localisation Cytoplasm
Nucleus
Nucleolus
Shuttles Between Cytoplasm And Nucleus/Nucleolus
Alternative ELISA Names Eukaryotic Translation Initiation Factor 6 ELISA kit
Eif-6 ELISA kit
B(2gcn Homolog ELISA kit
B4 Integrin Interactor ELISA kit
Cab ELISA kit
P27(Bbp ELISA kit
EIF6 ELISA kit
EIF3A ELISA kit
ITGB4BP ELISA kit
OK ELISA kit
SW-cl.27 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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