产品详情
简单介绍:
Anti-BAX antibody (30-110 aa) [6F11] (STJ97725)
详情介绍:
Host: | Mouse |
Applications: | IF/WB/IHC |
Reactivity: | Human/Rat/Mouse/Chicken/Silkworm |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Mouse monoclonal antibody anti-Apoptosis regulator BAX (30-110 aa) is suitable for use in Immunofluorescence, Western Blot and Immunohistochemistry research applications. |
Clonality: | Monoclonal |
Clone ID: | 6F11 |
Conjugation: | Unconjugated |
Isotype: | IgG1 |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | IF 1:50-200 WB 1:1000-2000 IHC 1:100-200 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | BAX |
Gene ID: | 581 |
Uniprot ID: | BAX_HUMAN |
Immunogen Region: | 30-110 aa |
Specificity: | Bax protein detects endogenous levels of BAX |
Immunogen: | Synthetic peptide of Bax at the amino acid range of 30-110 |
Post Translational Modifications | Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12. |
Function | Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. |
Protein Name | Apoptosis Regulator Bax Bcl-2-Like Protein 4 Bcl2-L-4 |
Database Links | Reactome: R-HSA-111457 Reactome: R-HSA-114294 Reactome: R-HSA-5620971 Reactome: R-HSA-6803204 Reactome: R-HSA-6804114 Reactome: R-HSA-8878166 Reactome: R-HSA-9603505 |
Cellular Localisation | Isoform Alpha: Mitochondrion Outer Membrane Single-Pass Membrane Protein Cytoplasm Nucleus Colocalizes With 14-3-3 Proteins In The Cytoplasm Under Stress Conditions Undergoes A Conformation Change That Causes Release From Jnk-Phosphorylated 14-3-3 Proteins And Translocation To The Mitochondrion Membrane Upon Sendai Virus Infection Recruited To The Mitochondrion Through Interaction With Irf3 Isoform Beta: Cytoplasm Isoform Gamma: Cytoplasm Isoform Delta: Cytoplasm |
Alternative Antibody Names | Anti-Apoptosis Regulator Bax antibody Anti-Bcl-2-Like Protein 4 antibody Anti-Bcl2-L-4 antibody Anti-BAX antibody Anti-BCL2L4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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