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  • 产品名称：Anti-APPL1 antibody (Internal) (STJ71081)

  • 产品型号：STJ71081-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-APPL1 antibody (Internal) (STJ71081)
详情介绍：
Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-APPL1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: APPL1
Gene ID: 26060
Uniprot ID: DP13A_HUMAN
Immunogen Region: Internal
Accession Number: NP_036228.1
Immunogen Sequence: NRYSRLSKKRENDK
Post Translational Modifications Phosphorylation at Ser-410 by PKA severely impairs binding to OCRL.
Function Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex. Functions as a positive regulator of innate immune response via activation of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1. Inhibits Fc-gamma receptor-mediated phagocytosis through PI3K/Akt signaling in macrophages. Regulates TLR4 signaling in activated macrophages. Involved in trafficking of the TGFBR1 from the endosomes to the nucleus via microtubules in a TRAF6-dependent manner. Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways. Required for fibroblast migration through HGF cell signaling. Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex.
Protein Name Dcc-Interacting Protein 13-Alpha
Dip13-Alpha
Adapter Protein Containing Ph Domain - Ptb Domain And Leucine Zipper Motif 1
Database Links Reactome: R-HSA-418889
Cellular Localisation Early Endosome Membrane
Peripheral Membrane Protein
Nucleus
Cytoplasm
Endosome
Cell Projection
Ruffle
Cytoplasmic Vesicle
Phagosome
Early Endosomal Membrane-Bound And Nuclear
Translocated Into The Nucleus Upon Release From Endosomal Membranes Following Internalization Of Egf
Alternative Antibody Names Anti-Dcc-Interacting Protein 13-Alpha antibody
Anti-Dip13-Alpha antibody
Anti-Adapter Protein Containing Ph Domain - Ptb Domain And Leucine Zipper Motif 1 antibody
Anti-APPL1 antibody
Anti-APPL antibody
Anti-DIP13A antibody
Anti-KIAA1428 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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