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  • 产品名称：Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)

  • 产品型号：STJE0015002
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Human ELAVL1 (ELAV Like Protein 1) Sandwich ELISA Kit Ready-To-Use (STJE0015002)
详情介绍：
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.118ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This ELAVL1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: ELAVL1
Gene ID: 1994
Uniprot ID: ELAV1_HUMAN
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Ubiquitous. Detected in brain, liver, thymus and muscle.
Post Translational Modifications Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD. Methylated at Arg-217 by CARM1 in macrophages in response to LPS challenge.
Function RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation. Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUUAGUUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR.
Protein Name Elav-Like Protein 1
Hu-Antigen R
Hur
Database Links Reactome: R-HSA-450520
Cellular Localisation Cytoplasm
Nucleus
Stress Granule
P-Body
Translocates Into The Cytoplasm Following Phosphorylation By Mapkapk2
Likewise
Phosphorylation By Prkcd Promotes Translocation From The Nucleus Into The Cytoplasm
Where It Is Associated With Free And Cytoskeleton-Bound Polysomes
Localizes To The Stress Granules In The Presence Of Plekhn1
Alternative ELISA Names Elav-Like Protein 1 ELISA kit
Hu-Antigen R ELISA kit
Hur ELISA kit
ELAVL1 ELISA kit
HUR ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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