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  • 产品名称：Anti-BCL10 antibody [4F8] (STJ97859)

  • 产品型号：STJ97859
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BCL10 antibody [4F8] (STJ97859)
详情介绍：
Host: Mouse
Applications: WB/IHC/IF/FC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-B-cell lymphoma/leukemia 10 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications.
Clonality: Monoclonal
Clone ID: 4F8
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 0.03% Sodium Azide.
Purification: Affinity purification
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:200-1:1000
IF 1:200-1:1000
FC 1:200-1:400
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BCL10
Gene ID: 8915
Uniprot ID: BCL10_HUMAN
Specificity: Bcl-10 Monoclonal Antibody detects endogenous levels of Bcl-10 protein.
Immunogen: Purified recombinant fragment of human Bcl-10 expressed in E. Coli.
Post Translational Modifications Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB. Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP.linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP. Proteolytically cleaved by MALT1.required for T-cell activation.
Function Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors.CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK.
Protein Name B-Cell Lymphoma/Leukemia 10
B-Cell Cll/Lymphoma 10
Bcl-10
Card-Containing Molecule Enhancing Nf-Kappa-B
Card-Like Apoptotic Protein
Hclap
Ced-3/Ich-1 Prodomain Homologous E10-Like Regulator
Ciper
Cellular Homolog Of Vcarmen
Ccarmen
Cellular-E10
C-E10
Mammalian Card-Containing Adapter Molecule E10
Me10
Database Links Reactome: R-HSA-1169091
Reactome: R-HSA-202424
Reactome: R-HSA-2871837
Reactome: R-HSA-5607764
Reactome: R-HSA-8866654
Cellular Localisation Cytoplasm
Perinuclear Region
Membrane Raft
Appears To Have A Perinuclear
Compact And Filamentous Pattern Of Expression
Also Found In The Nucleus Of Several Types Of Tumor Cells
Colocalized With Dpp4 In Membrane Rafts
Alternative Antibody Names Anti-B-Cell Lymphoma/Leukemia 10 antibody
Anti-B-Cell Cll/Lymphoma 10 antibody
Anti-Bcl-10 antibody
Anti-Card-Containing Molecule Enhancing Nf-Kappa-B antibody
Anti-Card-Like Apoptotic Protein antibody
Anti-Hclap antibody
Anti-Ced-3/Ich-1 Prodomain Homologous E10-Like Regulator antibody
Anti-Ciper antibody
Anti-Cellular Homolog Of Vcarmen antibody
Anti-Ccarmen antibody
Anti-Cellular-E10 antibody
Anti-C-E10 antibody
Anti-Mammalian Card-Containing Adapter Molecule E10 antibody
Anti-Me10 antibody
Anti-BCL10 antibody
Anti-CIPER antibody
Anti-CLAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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