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  • 产品名称：Anti-BCL11A antibody (STJA0008501)

  • 产品型号：STJA0008501
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-BCL11A antibody (STJA0008501)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-B-cell lymphoma/leukemia 11A is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BCL11A
Gene ID: 53335
Uniprot ID: BC11A_HUMAN
Specificity: This antibody detects endogenous levels of BCL11A at Human, Mouse
Immunogen: Synthesized peptide derived from human BCL11A
Post Translational Modifications Sumoylated with SUMO1.
Function Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1.hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development. May play a role in hematopoiesis. Essential factor in lymphopoiesis required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.
Protein Name B-Cell Lymphoma/Leukemia 11a
Bcl-11a
B-Cell Cll/Lymphoma 11a
Coup-Tf-Interacting Protein 1
Ecotropic Viral Integration Site 9 Protein Homolog
Evi-9
Zinc Finger Protein 856
Database Links Reactome: R-HSA-9700645
Reactome: R-HSA-9725370
Cellular Localisation Cytoplasm
Nucleus
Chromosome
Associates With The Nuclear Body
Colocalizes With Sumo1 And Senp2 In Nuclear Speckles
Isoform 1: Nucleus Matrix
Colocalizes With Bcl6 In Nuclear Paraspeckles
Isoform 2: Cytoplasm
Predominantly Localized In The Nucleus In Nuclear Paraspeckles
Isoform 3: Cytoplasm
Predominantly Localized In The Cytoplasm In The Absence Of Interaction With Isoform 1 And Isoform 2
In Presence Of Isoform 1 Or Isoform 2
Translocates From The Cytoplasm Into Nuclear Paraspeckles
Alternative Antibody Names Anti-B-Cell Lymphoma/Leukemia 11a antibody
Anti-Bcl-11a antibody
Anti-B-Cell Cll/Lymphoma 11a antibody
Anti-Coup-Tf-Interacting Protein 1 antibody
Anti-Ecotropic Viral Integration Site 9 Protein Homolog antibody
Anti-Evi-9 antibody
Anti-Zinc Finger Protein 856 antibody
Anti-BCL11A antibody
Anti-CTIP1 antibody
Anti-EVI9 antibody
Anti-KIAA1809 antibody
Anti-ZNF856 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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