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  • 产品名称：Anti-ADARB1 antibody (180-380) (STJ119156)

  • 产品型号：STJ119156
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ADARB1 antibody (180-380) (STJ119156)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ADARB1 (180-380) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADARB1
Gene ID: 104
Uniprot ID: RED1_HUMAN
Immunogen Region: 180-380
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human ADARB1 (NP_001103.1).
Immunogen Sequence: FETPDKAEPPFYVGSNGDDS FSSSGDLSLSASPVPASLAQ PPLPVLPPFPPPSGKNPVMI LNELRPGLKYDFLSESGESH AKSFVMSVVVDGQFFEGSGR NKKLAKARAAQSALAAIFNL HLDQTPSRQPIPSEGLQLHL PQVLADAVSRLVLGKFGDLT DNFSSPHARRKVLAGVVMTT GTDVKDAKVISVSTGTKCIN G
Tissue Specificity Highly expressed in brain and heart and at lower levels in placenta. Fair expression in lung, liver and kidney. Detected in brain, heart, kidney, lung and liver (at protein level). Isoform 5: Highly expressed in hippocampus and colon. Expressed in pediatric astrocytomas and the protein has a decreased RNA-editing activity. The decrease in RNA editing correlates with the grade of malignancy of the tumors, with the high grade tumors showing lower editing is seen.
Function Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins.pre-mRNA splicing by altering splice site recognition sequences.RNA stability by changing sequences involved in nuclease recognition.genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication.and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. Isoform 1: Has a lower catalytic activity than isoform 2. Isoform 2: Has a higher catalytic activity than isoform 1.
Protein Name Double-Stranded Rna-Specific Editase 1
Rna-Editing Deaminase 1
Rna-Editing Enzyme 1
Dsrna Adenosine Deaminase
Database Links Reactome: R-HSA-75102
Reactome: R-HSA-77042
Cellular Localisation Nucleus
Nucleolus
Shuttles Between Nucleoli And The Nucleoplasm
Isoform 1: Nucleus
Isoform 2: Nucleus
Alternative Antibody Names Anti-Double-Stranded Rna-Specific Editase 1 antibody
Anti-Rna-Editing Deaminase 1 antibody
Anti-Rna-Editing Enzyme 1 antibody
Anti-Dsrna Adenosine Deaminase antibody
Anti-ADARB1 antibody
Anti-ADAR2 antibody
Anti-DRADA2 antibody
Anti-RED1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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