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  • 产品名称：Glutamate Receptor 1 Blocking Peptide peptide (STJ504134)

  • 产品型号：STJ504134-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Glutamate Receptor 1 Blocking Peptide peptide (STJ504134)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Glutamate Receptor 1 Blocking Peptide is synthetically produced from the 850-950 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GRIA1
Gene ID: 2890
Uniprot ID: GRIA1_HUMAN
Immunogen Region: 850-950
Immunogen: Synthetic peptide taken within amino acid reigon 850-950.
Tissue Specificity Widely expressed in brain.
Post Translational Modifications Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation.
Function Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
Peptide Name Glutamate Receptor 1
Glur-1
Ampa-Selective Glutamate Receptor 1
Glur-A
Glur-K1
Glutamate Receptor Ionotropic - Ampa 1
Glua1
Database Links Reactome: R-HSA-204005
Reactome: R-HSA-399710
Reactome: R-HSA-399719
Reactome: R-HSA-416993
Reactome: R-HSA-438066
Reactome: R-HSA-5694530
Reactome: R-HSA-8849932
Reactome: R-HSA-9620244
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Endoplasmic Reticulum Membrane
Postsynaptic Cell Membrane
Postsynaptic Density Membrane
Cell Projection
Dendrite
Dendritic Spine
Early Endosome Membrane
Recycling Endosome Membrane
Presynapse
Synapse
Interaction With Cacng2
Cnih2 And Cnih3 Promotes Cell Surface Expression
Colocalizes With Pdlim4 In Early Endosomes
Displays A Somatodendritic Localization And Is Excluded From Axons In Neurons
Localized To Cone Photoreceptor Pedicles
Alternative Peptide Names Glutamate Receptor 1 protein
Glur-1 protein
Ampa-Selective Glutamate Receptor 1 protein
Glur-A protein
Glur-K1 protein
Glutamate Receptor Ionotropic - Ampa 1 protein
Glua1 protein
GRIA1 protein
GLUH1 protein
GLUR1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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