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  • 产品名称：GPCR GPR43 Blocking Peptide peptide (STJ504071)

  • 产品型号：STJ504071-250
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
GPCR GPR43 Blocking Peptide peptide (STJ504071)
详情介绍：
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: GPCR GPR43 Blocking Peptide is synthetically produced from the 280-330 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FFAR2
Gene ID: 2867
Uniprot ID: FFAR2_HUMAN
Immunogen Region: 280-330
Immunogen: Synthetic peptide taken within amino acid region 280-330 on human free fatty acid receptor 2 protein.
Tissue Specificity Expressed at relatively high levels in peripheral blood leukocytes and, to lesser extent, in spleen.
Function G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family. Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes. Among SCFAs, the fatty acids containing less than 6 carbons, the most potent activators are probably acetate, propionate and butyrate. Exhibits a SCFA-independent constitutive G protein-coupled receptor activity.
Peptide Name Free Fatty Acid Receptor 2
G-Protein Coupled Receptor 43
Database Links Reactome: R-HSA-416476
Reactome: R-HSA-444209
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Free Fatty Acid Receptor 2 protein
G-Protein Coupled Receptor 43 protein
FFAR2 protein
FFA2 protein
GPCR43 protein
GPR43 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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