产品详情
简单介绍:
Human CCL2 (C-C motif chemokine 2) CLIA Kit (STJC0000020)
详情介绍:
Applications: | CLIA |
Reactivity: | Human |
Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Sensitivity: | 4.69pg/mL |
Detection Limit: | 7.81~500pg/mL |
Short Description: | This human CCL2 kit is a highly sensitive in-vitro chemiluminescent immunoassay for the measurement of trace amounts of analytes. |
Storage Instruction: | If unopened the kit may be stored at 2-8°C for up to 1 month. If the kit will not be used within 1 month, store the components separately, according to the component table in the manual. |
Assay Time: | 3.5h |
Detection: | Chemiluminescence |
Gene Symbol: | CCL2 |
Gene ID: | 6347 |
Uniprot ID: | CCL2_HUMAN |
Specificity: | This kit recognizes Human MCP-1 in samples. No significant cross-reactivity or interference between Human MCP-1 and analogues was observed. |
Sample Type: | Serum, plasma and other biological fluids |
Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed in monocytes. |
Post Translational Modifications | Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. N-Glycosylated. |
Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. |
Protein Name | C-C Motif Chemokine 2 Hc11 Monocyte Chemoattractant Protein 1 Monocyte Chemotactic And Activating Factor Mcaf Monocyte Chemotactic Protein 1 Mcp-1 Monocyte Secretory Protein Je Small-Inducible Cytokine A2 |
Database Links | Reactome: R-HSA-380108 Reactome: R-HSA-380994 Reactome: R-HSA-6783783 Reactome: R-HSA-6785807 |
Cellular Localisation | Secreted |
Alternative CLIA Names | C-C Motif Chemokine 2 CLIA kit Hc11 CLIA kit Monocyte Chemoattractant Protein 1 CLIA kit Monocyte Chemotactic And Activating Factor CLIA kit Mcaf CLIA kit Monocyte Chemotactic Protein 1 CLIA kit Mcp-1 CLIA kit Monocyte Secretory Protein Je CLIA kit Small-Inducible Cytokine A2 CLIA kit CCL2 CLIA kit MCP1 CLIA kit SCYA2 CLIA kit |
Specificity | This kit recognizes Human MCP-1 in samples. No significant cross-reactivity or interference between Human MCP-1 and analogues was observed. |
Reproducibility | Both intra-CV and inter-CV are |
Information sourced from Uniprot.org
Item Specifications Storage
Micro CLIA Plate (Dismountable) | 96T: 8 wells ×12 strips strips | -20℃, 6 months |
Reference Standard | 96T: 2 vials 48T: 1 vial | -20℃, 6 months |
Concentrated Biotinylated Detection Ab (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃, 6 months |
Concentrated HRP Conjugate (100×) | 96T: 1 vial, 120 μL 60 μL | -20℃ (Protect from light), 6 months |
Reference Standard & Sample Diluent | 1 vial, 20 mL | 2-8°C, 6 months |
Biotinylated Detection Ab Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
HRP Conjugate Diluent | 1 vial, 14 mL | 2-8°C, 6 months |
Concentrated Wash Buffer (25×) | 1 vial, 30 mL | 2-8°C, 6 months |
Substrate Reagent A | 1 vial, 5 mL | 2-8℃ (Protect from light) |
Substrate Reagent B | 1 vial, 5 mL | 2-8℃ (Protect from light) |
Plate Sealer | 5 pieces | |
Manual | 1 copy | |
Certificate of Analysis | 1 copy |
Sample Type Range (%) Average Recovery (%)
Serum(n=8) | 100-112 | 106 |
EDTA plasma(n=8) | 90-104 | 98 |
Cell culture media(n=8) | 93-107 | 99 |
Intra-assay Precision Intra-assay Precision Intra-assay Precision Inter-assay Precision Inter-assay Precision Inter-assay Precision
Sample | 1.00 | 2.00 | 3.00 | 1.00 | 2.00 | 3.00 |
n | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 | 20.00 |
Mean (pg/mL) | 26.97 | 50.59 | 231.90 | 24.71 | 45.93 | 218.62 |
Standard deviation | 3.42 | 4.44 | 20.06 | 2.94 | 3.69 | 22.06 |
CV (%) | 12.68 | 8.78 | 8.65 | 11.90 | 8.03 | 10.09 |
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