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  • 产品名称：Mouse Adiponectin/Acrp30/ADIPOQ protein (Recombinant) (C-His) (STJP001459)

  • 产品型号：STJP001459
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse Adiponectin/Acrp30/ADIPOQ protein (Recombinant) (C-His) (STJP001459)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Adiponectin/Acrp30/ADIPOQ-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF12 at 2 Mu g/mL (100 Mu L/well) can bind Human TNFRSF12A with a linear range of 0.1-2.3 ng/mL.
Gene Symbol: Adipoq
Gene ID: 11450
Uniprot ID: ADIPO_MOUSE
Immunogen: Recombinant Mouse Adiponectin/Acrp30/ADIPOQ Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu18-Asn247) of mouse Adiponectin/Acrp30 (Accession #NP_033735.3) fused with a 6×His tag at the C-termi
Post Translational Modifications HMW complexes are more extensively glycosylated than smaller oligomers. Hydroxylation and glycosylation of the lysine residues within the collagen-like domain of adiponectin seem to be critically involved in regulating the formation and/or secretion of HMW complexes and consequently contribute to the insulin-sensitizing activity of adiponectin in hepatocytes. O-glycosylated. Not N-glycosylated O-linked glycans on hydroxylysine residues consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. O-linked glycosylation in the N-terminal is disialylated with the structure Neu5Acalpha2->8Neu5Acalpha2->3Gal. Sialylated by alpha 2,8-sialyltransferase III. Succination of Cys-39 by the Krebs cycle intermediate fumarate, which leads to S-(2-succinyl)cysteine residues, inhibits polymerization and secretion of adiponectin. Adiponectin is a major target for succination in both adipocytes and adipose tissue of diabetic mice. It was proposed that succination of proteins is a biomarker of mitochondrial stress and accumulation of Krebs cycle intermediates in adipose tissue in diabetes and that succination of adiponectin may contribute to the decrease in plasma adiponectin in diabetes.
Function Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Protein Name Adiponectin
30 Kda Adipocyte Complement-Related Protein
Adipocyte Complement-Related 30 Kda Protein
Acrp30
Adipocyte - C1q And Collagen Domain-Containing Protein
Adipocyte-Specific Protein Adipoq
Database Links Reactome: R-MMU-163680
Cellular Localisation Secreted
Alternative Protein Names Adiponectin protein
30 Kda Adipocyte Complement-Related Protein protein
Adipocyte Complement-Related 30 Kda Protein protein
Acrp30 protein
Adipocyte - C1q And Collagen Domain-Containing Protein protein
Adipocyte-Specific Protein Adipoq protein
Adipoq protein
Acdc protein
Acrp30 protein
Apm1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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