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  • 产品名称：Mouse CXCL10/IP10 protein (Recombinant) (C-hFc) (STJP001835)

  • 产品型号：STJP001835
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse CXCL10/IP10 protein (Recombinant) (C-hFc) (STJP001835)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CXCL10/IP10-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Cxcl10
Gene ID: 15945
Uniprot ID: CXL10_MOUSE
Immunogen Region: Ile22-Pro98
Immunogen: Recombinant Mouse CXCL10/IP10 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ile22-Pro98) of mouse CXCL10/IP10 (Accession #NP_067249.1) fused with and a hFc tag at the C-terminus.
Function Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects. Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites. Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization. In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation. Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization.
Protein Name C-X-C Motif Chemokine 10
10 Kda Interferon Gamma-Induced Protein
Gamma-Ip10
Ip-10
C7
Interferon-Gamma Induced Protein Crg-2
Small-Inducible Cytokine B10
Database Links Reactome: R-MMU-380108
Reactome: -MMU-418594
Cellular Localisation Secreted
Alternative Protein Names C-X-C Motif Chemokine 10 protein
10 Kda Interferon Gamma-Induced Protein protein
Gamma-Ip10 protein
Ip-10 protein
C7 protein
Interferon-Gamma Induced Protein Crg-2 protein
Small-Inducible Cytokine B10 protein
Cxcl10 protein
Crg2 protein
Ifi10 protein
Inp10 protein
Scyb10 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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