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  • 产品名称：Anti-ARHGEF7 antibody (595-805) (STJ500159)

  • 产品型号：STJ500159-100
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ARHGEF7 antibody (595-805) (STJ500159)
详情介绍：
Host: Rabbit
Applications: ELISA/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ARHGEF7 (595-805) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.59 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: ARHGEF7
Gene ID: 8874
Uniprot ID: ARHG7_HUMAN
Immunogen Region: 595-805
Immunogen: Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.
Post Translational Modifications Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. Phosphorylated on Ser-694 by CaMK1.enhancement of GEF activity and downstream activation of RAC1.
Function Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.
Protein Name Rho Guanine Nucleotide Exchange Factor 7
Beta-Pix
Cool-1
Pak-Interacting Exchange Factor Beta
P85
Database Links Reactome: R-HSA-182971
Reactome: R-HSA-193648
Reactome: R-HSA-3928664
Reactome: R-HSA-416482
Reactome: R-HSA-8980692
Reactome: R-HSA-9013148
Reactome: R-HSA-9013149
Reactome: R-HSA-9013406
Reactome: R-HSA-9013409
Reactome: R-HSA-9013420
Reactome: R-HSA-9013424
Reactome: R-HSA-9619229 Q14155-1
Cellular Localisation Cell Junction
Focal Adhesion
Cell Projection
Ruffle
Cytoplasm
Cell Cortex
Lamellipodium
Detected At Cell Adhesions
A Small Proportion Is Detected At Focal Adhesions
Alternative Antibody Names Anti-Rho Guanine Nucleotide Exchange Factor 7 antibody
Anti-Beta-Pix antibody
Anti-Cool-1 antibody
Anti-Pak-Interacting Exchange Factor Beta antibody
Anti-P85 antibody
Anti-ARHGEF7 antibody
Anti-COOL1 antibody
Anti-KIAA0142 antibody
Anti-P85SPR antibody
Anti-PAK3BP antibody
Anti-PIXB antibody
Anti-Nbla10314 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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