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  • 产品名称：Mouse IFNB1 protein (Recombinant) (STJP000325)

  • 产品型号：STJP000325
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse IFNB1 protein (Recombinant) (STJP000325)
详情介绍：
Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IFNB1-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 µm filtered PBS solution pH7.4.
Dilution Range: Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers.
Storage Instruction: The lyophilized protein is stable for at least 1 year from date of receipt at-20°C. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was determined by a viral resistance assay of Human WISH cells, and was found to be in the range of 1x10^8 IU/mg. NA
Gene Symbol: Ifnb1
Gene ID: 15977
Uniprot ID: IFNB_MOUSE
Immunogen Region: Mature chain
Immunogen: DNA sequence encoding the mature chain of Mouse IFNB1 was expressed in HEK293 Cells. NA
Immunogen Sequence: ALSINYKQLQ LQERTNIRKC QELLEQLNGK INLTYRADFK IPMEMTEKMQ KSYTAFAIQE MLQNVFLVFR NNFSSTGWNE TIVVRLLDEL HQQTVFLKTV LEEKQEERLT WEMSSTALHL KSYYWRVQRY LKLMKYNSYA WMVVRAEIFR NFLIIRRLTR NA
Post Translational Modifications This beta interferon does not have a disulfide bond.
Function Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins. Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth.
Protein Name Interferon Beta
Ifn-Beta
Database Links Reactome: R-MMU-909733
Reactome: -MMU-912694
Cellular Localisation Secreted
Alternative Protein Names Interferon Beta protein
Ifn-Beta protein
Ifnb1 protein
Ifb protein
Ifnb protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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