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  • 产品名称：Mouse IL-6RA/CD126 protein (Recombinant) (C-His) (STJP002005)

  • 产品型号：STJP002005
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse IL-6RA/CD126 protein (Recombinant) (C-His) (STJP002005)
详情介绍：
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IL-6RA/CD126-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Il6ra
Gene ID: 16194
Uniprot ID: IL6RA_MOUSE
Immunogen Region: Leu 20-Glu 357
Immunogen: Recombinant Mouse IL-6RA/CD126 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu 20-Glu 357) of Mouse Il6ra (Accession #NP_034689.2) fused with His tag at the C-terminus.
Post Translational Modifications A short soluble form is also released from the membrane by proteolysis. The sIL6R is formed by limited proteolysis of membrane-bound receptors, a process referred to as ectodomain shedding. mIL6R is cleaved by the proteases ADAM10 and ADAM17. Glycosylated. Glycosylation is dispensable for transport, signaling, and cell-surface turnover. Glycosylation at Asn-55 is a protease-regulatory exosite. Glycosylation is required for ADAM17-mediated proteolysis.
Function Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation leads to the regulation of the immune response, acute-phase reactions and hematopoiesis. The interaction with membrane-bound IL6R and IL6ST stimulates 'classic signaling', the restricted expression of the IL6R limits classic IL6 signaling to only a few tissues such as the liver and some cells of the immune system. Whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells. Interleukin-6 receptor subunit alpha: Signaling via the membrane-bound IL6R is mostly regenerative and anti-inflammatory (Probable). Drives naive CD4(+) T cells to the Th17 lineage, through 'cluster signaling' by dendritic cells. Soluble interleukin-6 receptor subunit alpha: Soluble form of IL6 receptor (sIL6R) that acts as an agonist of IL6 activity. The IL6:sIL6R complex (hyper-IL6) binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL6R in a process called IL6 'trans-signaling'. sIL6R is causative for the pro-inflammatory properties of IL6 and an important player in the development of chronic inflammatory diseases. In complex with IL6, is required for induction of VEGF production. Plays a protective role during liver injury, being required for maintenance of tissue regeneration. 'Trans-signaling' in central nervous system regulates energy and glucose homeostasis.
Protein Name Interleukin-6 Receptor Subunit Alpha
Il-6 Receptor Subunit Alpha
Il-6r Subunit Alpha
Il-6r-Alpha
Il-6ra
Il-6r 1
Cd Antigen Cd126 Cleaved Into - Soluble Interleukin-6 Receptor Subunit Alpha
Sil6r
Database Links Reactome: R-MMU-1059683
Reactome: -MMU-110056
Reactome: -MMU-112411
Cellular Localisation Interleukin-6 Receptor Subunit Alpha: Cell Membrane
Single-Pass Type I Membrane Protein
Soluble Interleukin-6 Receptor Subunit Alpha: Secreted
Alternative Protein Names Interleukin-6 Receptor Subunit Alpha protein
Il-6 Receptor Subunit Alpha protein
Il-6r Subunit Alpha protein
Il-6r-Alpha protein
Il-6ra protein
Il-6r 1 protein
Cd Antigen Cd126 Cleaved Into - Soluble Interleukin-6 Receptor Subunit Alpha protein
Sil6r protein
Il6ra protein
Il6r protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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